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BDBM50008491 CHEMBL356286::{3-[3-(2,4-Difluoro-phenyl)-[1,2,4]oxadiazol-5-ylmethyl]-4-oxo-3,4-dihydro-phthalazin-1-yl}-acetic acid

SMILES: OC(=O)Cc1nn(Cc2nc(no2)-c2ccc(F)cc2F)c(=O)c2ccccc12

InChI Key: InChIKey=MWKZXPWXMCRIES-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008491   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Aldose reductase (AR)


(Homo sapiens (Human))		BDBM50008491
PNG
(CHEMBL356286 | {3-[3-(2,4-Difluoro-phenyl)-[1,2,4]...)
Show SMILES OC(=O)Cc1nn(Cc2nc(no2)-c2ccc(F)cc2F)c(=O)c2ccccc12
Show InChI InChI=1S/C19H12F2N4O4/c20-10-5-6-13(14(21)7-10)18-22-16(29-24-18)9-25-19(28)12-4-2-1-3-11(12)15(23-25)8-17(26)27/h1-7H,8-9H2,(H,26,27)
PDB

UniProtKB/SwissProt
UniProtKB/TrEMBL

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 630n/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against aldose reductase isolated from human placenta

J Med Chem 35: 457-65 (1992)


BindingDB Entry DOI: 10.7270/Q28051K1
More data for this
Ligand-Target Pair