BDBM50008492 CHEMBL344526::[3-(7-Chloro-imidazo[1,2-a]pyridin-2-ylmethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-acetic acid

SMILES: OC(=O)Cc1nn(Cc2cn3ccc(Cl)cc3n2)c(=O)c2ccccc12

InChI Key: InChIKey=AVNGSRVYRUTXJU-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008492   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM50008492 (CHEMBL344526 | [3-(7-Chloro-imidazo[1,2-a]pyridin-...) Show SMILES OC(=O)Cc1nn(Cc2cn3ccc(Cl)cc3n2)c(=O)c2ccccc12 Show InChI InChI=1S/C18H13ClN4O3/c19-11-5-6-22-9-12(20-16(22)7-11)10-23-18(26)14-4-2-1-3-13(14)15(21-23)8-17(24)25/h1-7,9H,8,10H2,(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	37	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc Curated by ChEMBL					Assay Description In vitro inhibitory activity against aldose reductase isolated from human placenta				J Med Chem 35: 457-65 (1992) BindingDB Entry DOI: 10.7270/Q28051K1
					More data for this Ligand-Target Pair