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BDBM50008907 D-SACCHARIC ACID 1,4-LACTONE::D-Saccharic Acid 1,4-Lactone

SMILES: [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O

InChI Key: InChIKey=XECPAIJNBXCOBO-MMPJQOAZSA-N

Data: 20 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50008907   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi



Assay Description
β-Glucuronidase inhibitory activity was measured by quantifying the absorbance of para-nitrophenol which was formed from the substrate by the sp...

Bioorg Chem 70: 199-209 (2017)


Article DOI: 10.1016/j.bioorg.2016.12.011
BindingDB Entry DOI: 10.7270/Q2VH5MQ9
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Shiraz University of Medical Sciences

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate pre-incubated for 30 mins followed by substrate...

Bioorg Med Chem 28: (2020)

More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometry

Bioorg Med Chem Lett 24: 1825-9 (2014)


Article DOI: 10.1016/j.bmcl.2014.02.015
BindingDB Entry DOI: 10.7270/Q2R78GRJ
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.58E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...

Bioorg Med Chem 22: 3449-54 (2014)


Article DOI: 10.1016/j.bmc.2014.04.039
BindingDB Entry DOI: 10.7270/Q2057HHX
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.58E+4n/an/an/an/an/an/a



King Saud University

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide substrate incubated for 30 mins by spectrophotometry

Bioorg Med Chem 22: 6715-25 (2014)


Article DOI: 10.1016/j.bmc.2014.08.014
BindingDB Entry DOI: 10.7270/Q20Z74W7
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Universiti Teknologi MARA

Curated by ChEMBL


Assay Description
Inhibition of beta-D-glucuronidase (unknown origin) assessed as reduction in p-nitrophenol formation using p-nitrophenyl-beta-D-glucuronide substarte...

Bioorg Med Chem 23: 3119-25 (2015)


Article DOI: 10.1016/j.bmc.2015.04.081
BindingDB Entry DOI: 10.7270/Q2NZ89CV
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate assessed as p-nitrophenol formation after 30 mins b...

Bioorg Med Chem 23: 7394-404 (2015)


BindingDB Entry DOI: 10.7270/Q2765H56
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine beta-glucuronidase assessed as p-nitrophenol formation preincubated for 30 mins followed by addition of p-nitrophenyl-beta-D-glu...

Bioorg Med Chem 24: 1909-18 (2016)


BindingDB Entry DOI: 10.7270/Q28917RB
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate assessed as formation of p-nitrophenol incubate...

Bioorg Med Chem 24: 3696-704 (2016)


BindingDB Entry DOI: 10.7270/Q2CJ8GF6
More data for this
Ligand-Target Pair
Beta-glucuronidase (β-glucuronidase)


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta-glucuronidase assessed as p-nitrophenol formation preincubated for 30 mins followed by p-nitrophenyl-beta-D-glucuroni...

Bioorg Med Chem 24: 3624-35 (2016)


BindingDB Entry DOI: 10.7270/Q2D79DBM
More data for this
Ligand-Target Pair
Beta-glucuronidase


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta glucuronidase using p-nitrophenyl-beta-D-glucuronide as substrate preincubated for 30 mins followed by substrate addi...

Eur J Med Chem 125: 1289-1299 (2017)


BindingDB Entry DOI: 10.7270/Q2125VXZ
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.83E+4n/an/an/an/an/an/a



Imam Abdulrahman Bin Faisal University

Curated by ChEMBL


Assay Description
Inhibition of human beta-glucuronidase

Eur J Med Chem 143: 1757-1767 (2018)


Article DOI: 10.1016/j.ejmech.2017.10.071
BindingDB Entry DOI: 10.7270/Q23N25X1
More data for this
Ligand-Target Pair
Beta-glucuronidase


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Antagonistic activity by inhibition histamine H2 receptor from rats.

Eur J Med Chem 139: 849-864 (2017)


Article DOI: 10.1016/j.ejmech.2017.08.052
BindingDB Entry DOI: 10.7270/Q20P12HF
More data for this
Ligand-Target Pair
Beta-glucuronidase


(Bos taurus (Bovine))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



University of Karachi

Curated by ChEMBL


Assay Description
Inhibition of bovine liver beta glucuronidase assessed as p-nitrophenol formation after 30 mins by spectrophotometric method

Bioorg Med Chem 19: 4286-94 (2011)


Article DOI: 10.1016/j.bmc.2011.05.052
BindingDB Entry DOI: 10.7270/Q2FB55SC
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate incubated for 30 min prior to substrate additio...

Citation and Details

Article DOI: 10.1007/s00044-011-9804-0
BindingDB Entry DOI: 10.7270/Q24B346S
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.85E+4n/an/an/an/an/an/a



Jamia Hamdard (Deemed to be University)

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-D-glucuronide as substrate after 30 mins by spectrophotometric analysis

Eur J Med Chem 178: 687-704 (2019)


Article DOI: 10.1016/j.ejmech.2019.06.010
More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Imam Abdulrahman Bin Faisal University

Curated by ChEMBL


Assay Description
Inhibition of human beta-glucuronidase pre-incubated for 30 mins before p-nitrophenyl-beta-D-glucuronide substrate addition by spectrophotometry

Bioorg Med Chem 27: 3145-3155 (2019)


Article DOI: 10.1016/j.bmc.2019.05.049
More data for this
Ligand-Target Pair
Beta-glucuronidase (EcGUS)


(Escherichia coli (Enterobacteria))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 2.43E+4n/an/an/an/an/an/a



Wayne State University

Curated by ChEMBL


Assay Description
Inhibition of Escherichia coli beta-glucuronidase using 4-methylumbelliferyl-beta-D-glucuronide hydrate as substrate preincubated for 5 mins followed...

J Nat Prod 83: 825-833 (2020)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.58E+4n/an/an/an/an/an/a



University of KwaZulu-Natal

Curated by ChEMBL


Assay Description
Inhibition of beta-glucuronidase (unknown origin)

Eur J Med Chem 187: (2020)

More data for this
Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase)


(Homo sapiens (Human))		BDBM50008907
PNG
(D-SACCHARIC ACID 1,4-LACTONE | D-Saccharic Acid 1,...)
Show SMILES [H][C@@]1(OC(=O)[C@H](O)[C@H]1O)[C@H](O)C(O)=O |r|
Show InChI InChI=1S/C6H8O7/c7-1-2(8)6(12)13-4(1)3(9)5(10)11/h1-4,7-9H,(H,10,11)/t1-,2-,3+,4+/m1/s1
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n/an/a 4.84E+4n/an/an/an/an/an/a



Universiti Teknologi MARA (UiTM)



Assay Description
β-glucuronidase activity was determined by measuring absorbance at 405 nm of p-nitrophenol formed substrate by spectrophotometric method. 250 &#...

Bioorg Chem 71: 86-96 (2017)


Article DOI: 10.1016/j.bioorg.2017.01.015
BindingDB Entry DOI: 10.7270/Q2319TQN
More data for this
Ligand-Target Pair