BDBM50008991 CHEMBL3237939

SMILES: Cc1nn(c(Cl)c1C1C(C#N)=C(N)N(C2=C1C(=O)CCC2)c1cccnc1)-c1ccc(C)cc1

InChI Key: InChIKey=OPFYYYALZSRLSO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008991   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Epidermal growth factor receptor (Homo sapiens (Human))	BDBM50008991 (CHEMBL3237939) Show SMILES Cc1nn(c(Cl)c1C1C(C#N)=C(N)N(C2=C1C(=O)CCC2)c1cccnc1)-c1ccc(C)cc1 |c:15,t:11| Show InChI InChI=1S/C26H23ClN6O/c1-15-8-10-17(11-9-15)33-25(27)22(16(2)31-33)23-19(13-28)26(29)32(18-5-4-12-30-14-18)20-6-3-7-21(34)24(20)23/h4-5,8-12,14,23H,3,6-7,29H2,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.01E+4	n/a	n/a	n/a	n/a	n/a	n/a
Nanjing University Curated by ChEMBL					Assay Description Inhibition of autophosphorylation of recombinant EGFR cytoplasmic domain (645 to 1186) (unknown origin) expressed in Sf9 cells after 1 hr by DELFIA/t...				Eur J Med Chem 76: 549-57 (2014) Article DOI: 10.1016/j.ejmech.2014.01.018 BindingDB Entry DOI: 10.7270/Q2765GVR
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