BDBM50010877 1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-ethyl]-cyclohexanol (HCl)::CHEMBL419533

SMILES: CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1

InChI Key: InChIKey=NZIZWCBUQNNCKE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50010877   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A adrenergic receptor (Rattus norvegicus (Rat))	BDBM50010877 (1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...) Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1 Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	88	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of binding of [3H]imipramine to imipramine receptor in rat brain				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50010877 (1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...) Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1 Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of uptake of tritiated norepinephrine (NE) into rat brain synaptosomes				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50010877 (1-[2-Dimethylamino-1-(4-trifluoromethyl-phenyl)-et...) Show SMILES CN(C)CC(c1ccc(cc1)C(F)(F)F)C1(O)CCCCC1 Show InChI InChI=1S/C17H24F3NO/c1-21(2)12-15(16(22)10-4-3-5-11-16)13-6-8-14(9-7-13)17(18,19)20/h6-9,15,22H,3-5,10-12H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomes				J Med Chem 33: 2899-905 (1990) BindingDB Entry DOI: 10.7270/Q20C4WCM
					More data for this Ligand-Target Pair