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BDBM50011207 CHEMBL2368093::Sodium; 7-[6-chloro-4-(4-fluoro-phenyl)-2-isopropyl-quinolin-3-yl]-3,5-dihydroxy-hept-6-enoate

SMILES: [Na+].CC(C)c1nc2ccc(Cl)cc2c(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O

InChI Key: InChIKey=MHZYHYSNANGJTA-SEJJVXMHSA-M

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50011207   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
HMG-CoA reductase


(Rattus norvegicus (rat))		BDBM50011207
PNG
(CHEMBL2368093 | Sodium; 7-[6-chloro-4-(4-fluoro-ph...)
Show SMILES [Na+].CC(C)c1nc2ccc(Cl)cc2c(-c2ccc(F)cc2)c1\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O
Show InChI InChI=1S/C25H25ClFNO4.Na/c1-14(2)25-20(9-8-18(29)12-19(30)13-23(31)32)24(15-3-6-17(27)7-4-15)21-11-16(26)5-10-22(21)28-25;/h3-11,14,18-19,29-30H,12-13H2,1-2H3,(H,31,32);/q;+1/p-1/b9-8+;/t18-,19-;/m1./s1
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n/an/a 480n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Ability to inhibit microsomal preparation of HMG-CoA reductase in rat liver.

J Med Chem 34: 463-6 (1991)


BindingDB Entry DOI: 10.7270/Q2MS3TC4
More data for this
Ligand-Target Pair