BDBM50014651 2-Methyl-1,2,3,4-tetrahydro-isoquinoline::2-Methyl-1,2,3,4-tetrahydro-isoquinoline; hydrochloride::CHEMBL22053::CHEMBL545413
SMILES: CN1CCc2ccccc2C1
InChI Key: InChIKey=KYXSVGVQGFPNRQ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Curated by ChEMBL | Assay Description Compounds were tested for inhibition against human liver Monoamine oxidase B (competitive inhibition was observed) | J Med Chem 33: 147-52 (1990) BindingDB Entry DOI: 10.7270/Q26110X9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Adrenergic receptor alpha-2 (RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibition of [3H]clonidine binding to the rat alpha-2-adrenoceptor | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phenylethanolamine N-methyltransferase (Bos taurus (bovine)) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.36E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas Curated by ChEMBL | Assay Description Inhibitory activity against bovine adrenal phenylethanolamine N-methyl-transferase (PNMT) | Bioorg Med Chem Lett 9: 481-6 (1999) BindingDB Entry DOI: 10.7270/Q26Q20F9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | 2.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Texas Curated by ChEMBL | Assay Description Inhibition of human placental Monoamine oxidase A (competitive inhibition was observed) | J Med Chem 33: 147-52 (1990) BindingDB Entry DOI: 10.7270/Q26110X9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Prolylcarboxypeptidase (PRCP) (Homo sapiens (Human)) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle& Co. Curated by ChEMBL | Assay Description Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to phencyclidine receptor | J Med Chem 32: 1242-8 (1989) BindingDB Entry DOI: 10.7270/Q2CR5TXJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sigma non-opioid intracellular receptor 1 (RAT) | BDBM50014651![]() (2-Methyl-1,2,3,4-tetrahydro-isoquinoline | 2-Methy...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
G. D. Searle& Co. Curated by ChEMBL | Assay Description Inhibition of [3H]- N-allylnormetazocine ([3H]NANM) binding to sigma receptor | J Med Chem 32: 1242-8 (1989) BindingDB Entry DOI: 10.7270/Q2CR5TXJ | |||||||||||
More data for this Ligand-Target Pair |