BDBM50015094 CHEMBL152665::N-Hydroxy-2-phenyl-acetamide::N-hydroxy-2-phenylacetamide::Phenylacetohydroxamic acid

SMILES: ONC(=O)Cc1ccccc1

InChI Key: InChIKey=FPOQLQZHRCEVOT-UHFFFAOYSA-N

Data: 8 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50015094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cells(RBL-1)				J Med Chem 33: 992-8 (1990) BindingDB Entry DOI: 10.7270/Q2WW7GNM
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro inhibitory activity against RBL-1 5-LO				J Med Chem 30: 574-80 (1987) BindingDB Entry DOI: 10.7270/Q2QN67BB
					More data for this Ligand-Target Pair
Histone deacetylase 4 (Homo sapiens (Human))	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+4	n/a	n/a	n/a	n/a	n/a	25
Broad Institute of MIT and Harvard Curated by ChEMBL					Assay Description Inhibition of HDAC4 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...				J Med Chem 56: 1772-6 (2013) Article DOI: 10.1021/jm301355j BindingDB Entry DOI: 10.7270/Q2XK8GWB
					More data for this Ligand-Target Pair
Pseudolysin (Pseudomonas aeruginosa)	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.36E+4	n/a	n/a	n/a	n/a	n/a	n/a
The Scripps Research Institute Curated by ChEMBL					Assay Description Antagonist activity at Pseudomonas aeruginosa LasB using Abz-Ala-Gly-Leu-Ala-p-Nitro-Benzyl-Amide as substrate incubated for 30 mins prior to substra...				ACS Med Chem Lett 3: 668-672 (2012) Article DOI: 10.1021/ml300128f BindingDB Entry DOI: 10.7270/Q2BG2RVM
					More data for this Ligand-Target Pair
Histone deacetylase 8 (Homo sapiens (Human))	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.16E+4	n/a	n/a	n/a	n/a	n/a	25
Broad Institute of MIT and Harvard Curated by ChEMBL					Assay Description Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...				J Med Chem 56: 1772-6 (2013) Article DOI: 10.1021/jm301355j BindingDB Entry DOI: 10.7270/Q2XK8GWB
					More data for this Ligand-Target Pair
Cereblon/Histone deacetylase 6 (Homo sapiens (Human))	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	25
Broad Institute of MIT and Harvard Curated by ChEMBL					Assay Description Inhibition of HDAC6 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...				J Med Chem 56: 1772-6 (2013) Article DOI: 10.1021/jm301355j BindingDB Entry DOI: 10.7270/Q2XK8GWB
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase (Rattus norvegicus)	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	158	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Logarithmic value of inhibitory concentration against 5-lipoxygenase in rat basophilic leukemia cells (RBL-1)				J Med Chem 33: 992-8 (1990) BindingDB Entry DOI: 10.7270/Q2WW7GNM
					More data for this Ligand-Target Pair
Histone deacetylase 2 (Homo sapiens (Human))	BDBM50015094 (CHEMBL152665 | N-Hydroxy-2-phenyl-acetamide | N-hy...) Show SMILES ONC(=O)Cc1ccccc1 Show InChI InChI=1S/C8H9NO2/c10-8(9-11)6-7-4-2-1-3-5-7/h1-5,11H,6H2,(H,9,10)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>3.33E+4	n/a	n/a	n/a	n/a	n/a	25
Broad Institute of MIT and Harvard Curated by ChEMBL					Assay Description Inhibition of HDAC2 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl...				J Med Chem 56: 1772-6 (2013) Article DOI: 10.1021/jm301355j BindingDB Entry DOI: 10.7270/Q2XK8GWB
					More data for this Ligand-Target Pair