BDBM50015270 CHEMBL262958::N-[4-(2-Butyl-4-chloro-5-methoxycarbonylmethyl-imidazol-1-ylmethyl)-phenyl]-phthalamic acid
SMILES: CCCCc1nc(Cl)c(CC(=O)OC)n1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
InChI Key: InChIKey=VPGBXMVPAQLPJI-UHFFFAOYSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Angiotensin II type 1a (AT-1a) receptor (RABBIT) | BDBM50015270 (CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Displacement of [125I]-Sar1-Ile8-A II at the rabbit aorta angiotensin II receptor, type 1 | J Med Chem 36: 591-609 (1993) BindingDB Entry DOI: 10.7270/Q2P55MKH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II AT1B (RAT) | BDBM50015270 (CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Warner-Lambert Company Curated by ChEMBL | Assay Description Binding affinity against angiotensin II receptor type 1 (AT1) from rat liver. | J Med Chem 36: 1735-45 (1993) BindingDB Entry DOI: 10.7270/Q28W3CCP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (AT-1) type-1 (RAT) | BDBM50015270 (CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Innsbruck Curated by ChEMBL | Assay Description Inhibitory concentration that gives 50% displacement of specific binding at labeled angiotensin II type 1 receptor in rat adrenal cortical membranes. | J Med Chem 46: 716-26 (2003) Article DOI: 10.1021/jm021032v BindingDB Entry DOI: 10.7270/Q22B91RC | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (RAT) | BDBM50015270 (CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
E. I. du Pont de Nemours and Co., Inc. Curated by ChEMBL | Assay Description Ability to displace [3H]AII (2 nM) from its specific binding sites in rat adrenal cortical microsome preparation | J Med Chem 33: 1330-6 (1990) BindingDB Entry DOI: 10.7270/Q2PV6NMN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Angiotensin II receptor (RAT) | BDBM50015270 (CHEMBL262958 | N-[4-(2-Butyl-4-chloro-5-methoxycar...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL KEGG PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
E. I. du Pont de Nemours& Company, Inc. Curated by ChEMBL | Assay Description Inhibitory concentration that gave 50 percent displacement of specific binding of [3H]AII (2 nM) to Angiotensin II receptor | J Med Chem 33: 1312-29 (1990) BindingDB Entry DOI: 10.7270/Q2TM7DCT | |||||||||||
More data for this Ligand-Target Pair |