BDBM50017213 CHEMBL3287672::US10099993, Compound 21

SMILES: Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1

InChI Key: InChIKey=LAYLGZDXNCBQLL-UHFFFAOYSA-N

Data: 4 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50017213   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Metabotropic glutamate receptor 3 (Rattus norvegicus (Rat))	BDBM50017213 (CHEMBL3287672 | US10099993, Compound 21) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1 Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR3 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 3 (Homo sapiens (Human))	BDBM50017213 (CHEMBL3287672 | US10099993, Compound 21) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1 Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE US Patent									US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017213 (CHEMBL3287672 | US10099993, Compound 21) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1 Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	n/a	n/a	824	n/a	n/a	7.3	25
SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE US Patent					Assay Description Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...				US Patent US10099993 (2018) BindingDB Entry DOI: 10.7270/Q2Z89FFP
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50017213 (CHEMBL3287672 | US10099993, Compound 21) Show SMILES Cc1c(O)c(ccc1OCCCCOc1ccc(cc1)C(O)=O)C(=O)CC1CCCC1 Show InChI InChI=1S/C25H30O6/c1-17-23(13-12-21(24(17)27)22(26)16-18-6-2-3-7-18)31-15-5-4-14-30-20-10-8-19(9-11-20)25(28)29/h8-13,18,27H,2-7,14-16H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	824	n/a	n/a	n/a	n/a
Sanford-Burnham Medical Research Institute Curated by ChEMBL					Assay Description Positive allosteric modulation of rat mGluR2 receptor expressed in HEK293 cells assessed as potentiation of glutamate-induced thallium flux incubated...				J Med Chem 57: 4154-72 (2014) Article DOI: 10.1021/jm5000563 BindingDB Entry DOI: 10.7270/Q2GH9KH9
					More data for this Ligand-Target Pair