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SMILES: COC(=O)c1ccc(OCCCN2CCC(CC2)C(O)(c2ccc(F)cc2)c2ccc(F)cc2)cc1

InChI Key: InChIKey=DNJLISQLMWIPEU-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50017372   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))		BDBM50017372
PNG
(4-(3-{4-[Bis-(4-fluoro-phenyl)-hydroxy-methyl]-pip...)
Show SMILES COC(=O)c1ccc(OCCCN2CCC(CC2)C(O)(c2ccc(F)cc2)c2ccc(F)cc2)cc1
Show InChI InChI=1S/C29H31F2NO4/c1-35-28(33)21-3-13-27(14-4-21)36-20-2-17-32-18-15-24(16-19-32)29(34,22-5-9-25(30)10-6-22)23-7-11-26(31)12-8-23/h3-14,24,34H,2,15-20H2,1H3
UniProtKB/SwissProt

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PubMed
n/an/a 63n/an/an/an/an/an/a



A.H. Robins Company

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against Tritiated [3H]- mepyramine binding to histamine H1 receptor in guinea pig cerebral cortex

J Med Chem 32: 105-18 (1989)


BindingDB Entry DOI: 10.7270/Q2WM1CD6
More data for this
Ligand-Target Pair