BDBM50018618 6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one::CHEMBL30402

SMILES: O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12

InChI Key: InChIKey=DGILEKCXNQODOP-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50018618   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018618 (6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyr...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12 |c:4| Show InChI InChI=1S/C17H14N4O/c22-17-10-9-14(19-20-17)12-5-7-13(8-6-12)21-11-18-15-3-1-2-4-16(15)21/h1-8,11H,9-10H2,(H,20,22)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50018618 (6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyr...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12 |c:4| Show InChI InChI=1S/C17H14N4O/c22-17-10-9-14(19-20-17)12-5-7-13(8-6-12)21-11-18-15-3-1-2-4-16(15)21/h1-8,11H,9-10H2,(H,20,22)	PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018618 (6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyr...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12 |c:4| Show InChI InChI=1S/C17H14N4O/c22-17-10-9-14(19-20-17)12-5-7-13(8-6-12)21-11-18-15-3-1-2-4-16(15)21/h1-8,11H,9-10H2,(H,20,22)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018618 (6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyr...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12 |c:4| Show InChI InChI=1S/C17H14N4O/c22-17-10-9-14(19-20-17)12-5-7-13(8-6-12)21-11-18-15-3-1-2-4-16(15)21/h1-8,11H,9-10H2,(H,20,22)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018618 (6-(4-Benzoimidazol-1-yl-phenyl)-4,5-dihydro-2H-pyr...) Show SMILES O=C1CCC(=NN1)c1ccc(cc1)-n1cnc2ccccc12 |c:4| Show InChI InChI=1S/C17H14N4O/c22-17-10-9-14(19-20-17)12-5-7-13(8-6-12)21-11-18-15-3-1-2-4-16(15)21/h1-8,11H,9-10H2,(H,20,22)	PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	2.20E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair