BDBM50018620 6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one::CHEMBL58728

SMILES: O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1

InChI Key: InChIKey=ZUOGTJVNQLGUKO-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50018620   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE II enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition cGMP PDE I enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE II enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	4.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE I enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.80E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cGMP PDE II enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50018620 (6-[4-(1H-Imidazol-2-yl)-phenyl]-2H-pyridazin-3-one...) Show SMILES O=c1ccc(n[nH]1)-c1ccc(cc1)-c1ncc[nH]1 Show InChI InChI=1S/C13H10N4O/c18-12-6-5-11(16-17-12)9-1-3-10(4-2-9)13-14-7-8-15-13/h1-8H,(H,14,15)(H,17,18)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE III enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair