BDBM50018622 6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazin-3-one::CHEMBL30367

SMILES: O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1

InChI Key: InChIKey=WZXOPORJXLMKNA-UHFFFAOYSA-N

Data: 10 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50018622   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cGMP PDE II enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 3 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE III enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cAMP PDE I enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition cGMP PDE I enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cGMP PDE II enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Phosphodiesterase 1 (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	9.30E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibition of cAMP PDE I enzyme				J Med Chem 30: 1963-72 (1987) BindingDB Entry DOI: 10.7270/Q28K79P9
					More data for this Ligand-Target Pair
Homo sapiens phosphodiesterase 2A (PDE2A) (Homo sapiens (Human))	BDBM50018622 (6-(3-Imidazol-1-yl-phenyl)-4,5-dihydro-2H-pyridazi...) Show SMILES O=C1CCC(=NN1)c1cccc(c1)-n1ccnc1 |c:4| Show InChI InChI=1S/C13H12N4O/c18-13-5-4-12(15-16-13)10-2-1-3-11(8-10)17-7-6-14-9-17/h1-3,6-9H,4-5H2,(H,16,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.40E+5	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Inhibitory concentration against cGMP PDE II enzyme in guinea pig				J Med Chem 30: 1955-62 (1987) BindingDB Entry DOI: 10.7270/Q27S7MS4
					More data for this Ligand-Target Pair