BDBM50019203 2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4(3H)-one (23)::CHEMBL3289115

SMILES: CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1

InChI Key: InChIKey=ACVBJGJCXIWMBN-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50019203   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Thymidine phosphorylase (TP) (Escherichia coli (Enterobacteria))	BDBM50019203 (2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4...) Show SMILES CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1 Show InChI InChI=1S/C16H14N2O3/c1-2-21-14-9-10(7-8-13(14)19)15-17-12-6-4-3-5-11(12)16(20)18-15/h3-9,19H,2H2,1H3,(H,17,18,20)	PDB B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.56E+5	n/a	n/a	n/a	n/a	7.0	n/a
University of Karachi					Assay Description TP inhibition assay was performed spectrophotometrically. The method of Bera et al. was followed with slight modifications. Reaction mixture of 200 µ...				Bioorg Chem 63: 142-51 (2015) Article DOI: 10.1016/j.bioorg.2015.10.006 BindingDB Entry DOI: 10.7270/Q2C8282R
					More data for this Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase) (Homo sapiens (Human))	BDBM50019203 (2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4...) Show SMILES CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1 Show InChI InChI=1S/C16H14N2O3/c1-2-21-14-9-10(7-8-13(14)19)15-17-12-6-4-3-5-11(12)16(20)18-15/h3-9,19H,2H2,1H3,(H,17,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of KwaZulu-Natal Curated by ChEMBL					Assay Description Inhibition of beta-glucuronidase (unknown origin) using p-nitrophenyl-beta-d-glucuronide as substrate after 30 mins				Eur J Med Chem 187: (2020)
					More data for this Ligand-Target Pair
beta-Glucuronidase (β-glucuronidase) (Homo sapiens (Human))	BDBM50019203 (2-(3'-Ethoxy-4'-hydroxyphenyl)quinazolin-4...) Show SMILES CCOc1cc(ccc1O)-c1nc2ccccc2c(=O)[nH]1 Show InChI InChI=1S/C16H14N2O3/c1-2-21-14-9-10(7-8-13(14)19)15-17-12-6-4-3-5-11(12)16(20)18-15/h3-9,19H,2H2,1H3,(H,17,18,20)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.17E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Karachi Curated by ChEMBL					Assay Description Inhibition of beta-glucuronidase activity (unknown origin) assessed as p-nitrophenol formation after 30 mins using p-nitrophenyl-beta-D-glucuronide a...				Bioorg Med Chem 22: 3449-54 (2014) Article DOI: 10.1016/j.bmc.2014.04.039 BindingDB Entry DOI: 10.7270/Q2057HHX
					More data for this Ligand-Target Pair