null

SMILES: NC(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1

InChI Key: InChIKey=LRNJBEMBOKBVLE-KRWDZBQOSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 500207   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 3-kinase regulatory subunit beta (Homo sapiens (Human))	BDBM500207 (US11021467, Compound 64) Show SMILES NC(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1 |r| Show InChI InChI=1S/C22H24ClN9O2/c23-13-4-3-5-14-16(13)21(34)32(9-2-1-6-15(25)33)20(28-14)17(11-7-8-11)29-19-12(10-24)18(26)30-22(27)31-19/h3-5,11,17H,1-2,6-9H2,(H2,25,33)(H5,26,27,29,30,31)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...				US Patent US11021467 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (Homo sapiens (Human))	BDBM500207 (US11021467, Compound 64) Show SMILES NC(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1 |r| Show InChI InChI=1S/C22H24ClN9O2/c23-13-4-3-5-14-16(13)21(34)32(9-2-1-6-15(25)33)20(28-14)17(11-7-8-11)29-19-12(10-24)18(26)30-22(27)31-19/h3-5,11,17H,1-2,6-9H2,(H2,25,33)(H5,26,27,29,30,31)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...				US Patent US11021467 (2021)
					More data for this Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform (Homo sapiens (Human))	BDBM500207 (US11021467, Compound 64) Show SMILES NC(=O)CCCCn1c(nc2cccc(Cl)c2c1=O)[C@@H](Nc1nc(N)nc(N)c1C#N)C1CC1 |r| Show InChI InChI=1S/C22H24ClN9O2/c23-13-4-3-5-14-16(13)21(34)32(9-2-1-6-15(25)33)20(28-14)17(11-7-8-11)29-19-12(10-24)18(26)30-22(27)31-19/h3-5,11,17H,1-2,6-9H2,(H2,25,33)(H5,26,27,29,30,31)/t17-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Gilead Sciences, Inc. US Patent					Assay Description Class I PI3K isoforms were expressed and purified as heterodimeric recombinant proteins. All assay reagents and buffers for the TR-FRET assay were pu...				US Patent US11021467 (2021)
					More data for this Ligand-Target Pair