BDBM50021237 CHEMBL300185::CHEMBL555597::[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-dimethyl-amine::[6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-dimethyl-amine; hydrochloride

SMILES: CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1

InChI Key: InChIKey=JOESEFFNJUCYQM-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50021237   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	440	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dopamine uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.20	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of 5-HT uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair
Sodium-dependent dopamine transporter (Rattus norvegicus (rat))	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	620	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of dopamine uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair
Monoamine transporters; Norepininephrine & dopamine (Rattus norvegicus)	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	350	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of noradrenaline uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair
Sodium-dependent serotonin transporter (Rattus norvegicus (rat))	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of 5-HT uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair
Norepinephrine Monoamine transporters (Rattus norvegicus)	BDBM50021237 (CHEMBL300185 | CHEMBL555597 | [6-Fluoro-3-(4-fluor...) Show SMILES CN(C)C1CC(c2ccc(F)cc12)c1ccc(F)cc1 Show InChI InChI=1S/C17H17F2N/c1-20(2)17-10-15(11-3-5-12(18)6-4-11)14-8-7-13(19)9-16(14)17/h3-9,15,17H,10H2,1-2H3	Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibition of noradrenaline uptake in rat synaptosomal fraction				J Med Chem 28: 1817-28 (1986) BindingDB Entry DOI: 10.7270/Q29W0G1M
					More data for this Ligand-Target Pair