BDBM50022401 8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrahydro-1'H-imidazole)]-2',5'-dione(1/8H2O)::CHEMBL420024

SMILES: O=C1NC(=O)C2(CCOc3c(cccc23)-c2ccccc2)N1

InChI Key: InChIKey=YOKWLJMQDFBYCL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50022401   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (ALR2) (Bos taurus (Cattle))	BDBM50022401 (8-phenylspiro[3,4-dihydro-2H-chromene-4,4'-(tetrah...) Show SMILES O=C1NC(=O)C2(CCOc3c(cccc23)-c2ccccc2)N1 Show InChI InChI=1S/C17H14N2O3/c20-15-17(19-16(21)18-15)9-10-22-14-12(7-4-8-13(14)17)11-5-2-1-3-6-11/h1-8H,9-10H2,(H2,18,19,20,21)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Central Research Curated by ChEMBL					Assay Description In vitro inhibitory activity towards partially purified calf lens aldose reductase; value ranges from 10E-6 - 10E-7				J Med Chem 31: 230-43 (1988) BindingDB Entry DOI: 10.7270/Q27D2VQF
					More data for this Ligand-Target Pair