BDBM50033779 (R)-4-Ethyl-4-hydroxy-7-[5-methyl-7-nitro-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-1,4,7,8-tetrahydro-pyrano[3,4-f]indolizine-3,6,10-trione::CHEMBL367649
SMILES: CC[C@]1(O)C(=O)OCc2c1cc1C(=O)\C(Cn1c2=O)=C1\C(=O)Nc2c1cc(C)cc2[N+]([O-])=O
InChI Key: InChIKey=IIEZWWXBZMHQBH-UPMCQBDUSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
DNA topoisomerase I (Topo I) (Homo sapiens (Human)) | BDBM50033779 ((R)-4-Ethyl-4-hydroxy-7-[5-methyl-7-nitro-2-oxo-1,...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Research Institute Curated by ChEMBL | Assay Description Inhibition of bovine topoisomerase I, using cleavable complex assay. | J Med Chem 38: 906-11 (1995) BindingDB Entry DOI: 10.7270/Q2XG9Q55 | |||||||||||
More data for this Ligand-Target Pair |