BDBM50034266 3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-benzyl)-5-(4-methoxy-phenyl)-5H-furan-2-one::CHEMBL10996

SMILES: COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1

InChI Key: InChIKey=RYEVVTBWAHSOKY-UHFFFAOYSA-N

Data: 5 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50034266   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50034266 (3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-ben...) Show SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1 |t:7| Show InChI InChI=1S/C25H20Cl2O5/c1-30-18-8-3-15(4-9-18)13-20-23(16-5-12-21(26)22(27)14-16)24(28)32-25(20,29)17-6-10-19(31-2)11-7-17/h3-12,14,29H,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	310	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Tested for antagonistic activity against Endothelin A receptor in the rabbit renal artery vascular smooth muscle cells.				J Med Chem 38: 1259-63 (1995) BindingDB Entry DOI: 10.7270/Q2WH2P1B
					More data for this Ligand-Target Pair
EDNRB (Homo sapiens (Human))	BDBM50034266 (3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-ben...) Show SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1 |t:7| Show InChI InChI=1S/C25H20Cl2O5/c1-30-18-8-3-15(4-9-18)13-20-23(16-5-12-21(26)22(27)14-16)24(28)32-25(20,29)17-6-10-19(31-2)11-7-17/h3-12,14,29H,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Tested for antagonistic activity against Endothelin B receptor in the humans (CHO expressed).				J Med Chem 38: 1259-63 (1995) BindingDB Entry DOI: 10.7270/Q2WH2P1B
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50034266 (3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-ben...) Show SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1 |t:7| Show InChI InChI=1S/C25H20Cl2O5/c1-30-18-8-3-15(4-9-18)13-20-23(16-5-12-21(26)22(27)14-16)24(28)32-25(20,29)17-6-10-19(31-2)11-7-17/h3-12,14,29H,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Binding affinity against human cloned endothelin A receptor expressed in LTK-cells				J Med Chem 40: 1063-74 (1997) Article DOI: 10.1021/jm9606507 BindingDB Entry DOI: 10.7270/Q27P8XG5
					More data for this Ligand-Target Pair
EDNRB (Homo sapiens (Human))	BDBM50034266 (3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-ben...) Show SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1 |t:7| Show InChI InChI=1S/C25H20Cl2O5/c1-30-18-8-3-15(4-9-18)13-20-23(16-5-12-21(26)22(27)14-16)24(28)32-25(20,29)17-6-10-19(31-2)11-7-17/h3-12,14,29H,13H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Binding affinity against human cloned Endothelin B receptor expressed in CHO-K1 cells				J Med Chem 40: 1063-74 (1997) Article DOI: 10.1021/jm9606507 BindingDB Entry DOI: 10.7270/Q27P8XG5
					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50034266 (3-(3,4-Dichloro-phenyl)-5-hydroxy-4-(4-methoxy-ben...) Show SMILES COc1ccc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc(Cl)c(Cl)c2)cc1 |t:7| Show InChI InChI=1S/C25H20Cl2O5/c1-30-18-8-3-15(4-9-18)13-20-23(16-5-12-21(26)22(27)14-16)24(28)32-25(20,29)17-6-10-19(31-2)11-7-17/h3-12,14,29H,13H2,1-2H3	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Warner-Lambert Company Curated by ChEMBL					Assay Description Antagonistic activity against human Endothelin A receptor expressed in LtK				J Med Chem 38: 1259-63 (1995) BindingDB Entry DOI: 10.7270/Q2WH2P1B
					More data for this Ligand-Target Pair