BDBM50035431 5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one::5-Butyl-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2-(2-trifluoromethyl-phenyl)-2,4-dihydro-[1,2,4]triazol-3-one::CHEMBL19018
SMILES: CCCCc1nn(-c2ccccc2C(F)(F)F)c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
InChI Key: InChIKey=DWXCNNUZEBMCMR-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
NeoGenesis, Inc. Curated by ChEMBL | Assay Description Binding affinity to Angiotensin II receptor, type 1 | J Med Chem 43: 1993-2006 (2000) BindingDB Entry DOI: 10.7270/Q2MP53ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro inhibitory activity against angiotensin II rabbit aorta AT1 receptor using radioligand [125I]-Sar Ile-AII | J Med Chem 37: 2808-24 (1994) BindingDB Entry DOI: 10.7270/Q2M907QM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Tested for in vitro binding affinity against angiotensin I (AT1) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a... | J Med Chem 37: 4464-78 (1995) BindingDB Entry DOI: 10.7270/Q2WD3ZK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 angiotensin II receptor (RAT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro binding affinity against angiotensin II (AT2) receptor to competitively block the specific binding of [125I]- [Sar1,Ile8] AII to a rat mid b... | J Med Chem 37: 4464-78 (1995) BindingDB Entry DOI: 10.7270/Q2WD3ZK5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-2 angiotensin II receptor (RAT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro inhibitory activity against angiotensin II rat midbrain AT2 receptor using radioligand [125I]-Sar Ile-AII | J Med Chem 37: 2808-24 (1994) BindingDB Entry DOI: 10.7270/Q2M907QM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.20E+9 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin | Citation and Details Article DOI: 10.1007/s00044-009-9197-5 BindingDB Entry DOI: 10.7270/Q2H41V9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
The M. S. University of Baroda Curated by ChEMBL | Assay Description Displacement of [125I]-Sar1Ile8-angiotensin 2 from angiotensin AT1 receptor in rabbit aortic membranes | Bioorg Med Chem 18: 8418-56 (2010) Article DOI: 10.1016/j.bmc.2010.10.043 BindingDB Entry DOI: 10.7270/Q2H70G3T | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
NeoGenesis, Inc. Curated by ChEMBL | Assay Description Inhibitory activity against Angiotensin II receptor, type 1 binding | J Med Chem 43: 1993-2006 (2000) BindingDB Entry DOI: 10.7270/Q2MP53ZS | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at angiotensin 2 type-1 receptor in Oryctolagus cuniculus (rabbit) aorta in presence of bovine serum albumin | Citation and Details Article DOI: 10.1007/s00044-009-9197-5 BindingDB Entry DOI: 10.7270/Q2H41V9D | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | Article | n/a | n/a | 0.780 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA Curated by ChEMBL | Assay Description Displacement of 125I[Sar,Ile] from rabbit aorta membrane Angiotensin II receptor type 1 | Bioorg Med Chem Lett 4: 115-120 (1994) Article DOI: 10.1016/S0960-894X(01)81132-X BindingDB Entry DOI: 10.7270/Q2057FT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Type-1 angiotensin II receptor (RABBIT) | BDBM50035431 (5-Butyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmeth...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description In vitro antagonistic activity for angiotensin II receptor, type 1 by displacing 125I[Sar, ILe8 ]AII radioligand in rabbit aorta membrane without usi... | J Med Chem 36: 2558-68 (1993) BindingDB Entry DOI: 10.7270/Q2KP817C | |||||||||||
More data for this Ligand-Target Pair |