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SMILES: O=C(Nc1ccc2cn[nH]c2c1)c1c[nH]c2ccccc2c1=O

InChI Key: InChIKey=CMARHFYIVHRDDR-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50035597   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Cystic fibrosis transmembrane conductance regulator


(Homo sapiens (Human))		BDBM50035597
PNG
(CHEMBL3356638)
Show SMILES O=C(Nc1ccc2cn[nH]c2c1)c1c[nH]c2ccccc2c1=O
Show InChI InChI=1S/C17H12N4O2/c22-16-12-3-1-2-4-14(12)18-9-13(16)17(23)20-11-6-5-10-8-19-21-15(10)7-11/h1-9H,(H,18,22)(H,19,21)(H,20,23)
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/an/an/a 5.60E+3n/an/an/an/a



Vertex Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay

J Med Chem 57: 9776-95 (2014)


Article DOI: 10.1021/jm5012808
BindingDB Entry DOI: 10.7270/Q2TH8P9K
More data for this
Ligand-Target Pair