BDBM50035603 CHEMBL3356631

SMILES: CCc1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1

InChI Key: InChIKey=VVAFRGHUXOWJDW-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50035603   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cystic fibrosis transmembrane conductance regulator (Homo sapiens (Human))	BDBM50035603 (CHEMBL3356631) Show SMILES CCc1ccc(NC(=O)c2c[nH]c3ccccc3c2=O)cc1 Show InChI InChI=1S/C18H16N2O2/c1-2-12-7-9-13(10-8-12)20-18(22)15-11-19-16-6-4-3-5-14(16)17(15)21/h3-11H,2H2,1H3,(H,19,21)(H,20,22)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	800	n/a	n/a	n/a	n/a
Vertex Pharmaceuticals Inc Curated by ChEMBL					Assay Description Potentiation of human CFTR F508del mutant expressed in mouse NIH-3T3 cells after 30 mins by fluorescent voltage sensing optical assay				J Med Chem 57: 9776-95 (2014) Article DOI: 10.1021/jm5012808 BindingDB Entry DOI: 10.7270/Q2TH8P9K
					More data for this Ligand-Target Pair