BDBM50038848 2-(4-bromo-2-fluorobenzyl)-7-chloro-1H,2'H,5'H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetrone::CHEMBL292505

SMILES: Fc1cc(Br)ccc1CN1C(=O)c2cc(Cl)ccc2C2(CC(=O)NC2=O)C1=O

InChI Key: InChIKey=RWBKFSYZRVEEHD-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038848   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (ALR2) (Bos taurus (Cattle))	BDBM50038848 (2-(4-bromo-2-fluorobenzyl)-7-chloro-1H,2'H,5'H-spi...) Show SMILES Fc1cc(Br)ccc1CN1C(=O)c2cc(Cl)ccc2C2(CC(=O)NC2=O)C1=O Show InChI InChI=1S/C19H11BrClFN2O4/c20-10-2-1-9(14(22)5-10)8-24-16(26)12-6-11(21)3-4-13(12)19(18(24)28)7-15(25)23-17(19)27/h1-6H,7-8H2,(H,23,25,27)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparation				J Med Chem 37: 2043-58 (1994) Checked by Author BindingDB Entry DOI: 10.7270/Q2BR8STM
					More data for this Ligand-Target Pair