BDBM50038862 2-(4-chlorobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4,3'-pyrrolidine]-1,2',3,5'(2H)-tetrone::CHEMBL59663

SMILES: Clc1ccc(CN2C(=O)c3ccccc3C3(CC(=O)NC3=O)C2=O)cc1

InChI Key: InChIKey=NXUWEJFLRFLSFK-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50038862   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (ALR2) (Bos taurus (Cattle))	BDBM50038862 (2-(4-chlorobenzyl)-1H,2'H,5'H-spiro[isoquinoline-4...) Show SMILES Clc1ccc(CN2C(=O)c3ccccc3C3(CC(=O)NC3=O)C2=O)cc1 Show InChI InChI=1S/C19H13ClN2O4/c20-12-7-5-11(6-8-12)10-22-16(24)13-3-1-2-4-14(13)19(18(22)26)9-15(23)21-17(19)25/h1-8H,9-10H2,(H,21,23,25)	PDB GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	22	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description In vitro inhibition of aldose reductase activity in a partially purified bovine lens preparation				J Med Chem 37: 2043-58 (1994) Checked by Author BindingDB Entry DOI: 10.7270/Q2BR8STM
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