null
SMILES: COc1ccc(cc1)C(OCCN1CCC[C@@H](C1)C(O)=O)(c1ccc(OC)cc1)c1ccc(OC)cc1
InChI Key: InChIKey=VDLDUZLDZBVOAS-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse GAT1 expressed in HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 35 mins by liquid scintillation metho... | Citation and Details Article DOI: 10.1016/j.ejmech.2019.111920 BindingDB Entry DOI: 10.7270/Q2FJ2MJJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 3 (Mus musculus) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.55E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse GAT4 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113512 BindingDB Entry DOI: 10.7270/Q2R21568 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Rattus norvegicus) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 8.51E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse GAT1 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113512 BindingDB Entry DOI: 10.7270/Q2R21568 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 2 (Rattus norvegicus) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Inhibitory activity against rat GABA transporter-2 (rGAT2) | J Med Chem 37: 2334-42 (1994) BindingDB Entry DOI: 10.7270/Q2P849XX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 1 (Homo sapiens (Human)) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.70E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of human GAT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem 21: 4938-50 (2013) Article DOI: 10.1016/j.bmc.2013.06.063 BindingDB Entry DOI: 10.7270/Q2NZ891C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 2 (Homo sapiens (Human)) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of human GAT2 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem 21: 4938-50 (2013) Article DOI: 10.1016/j.bmc.2013.06.063 BindingDB Entry DOI: 10.7270/Q2NZ891C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 3 (Mus musculus) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 5.13E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of mouse GAT3 expressed in human HEK293 cell line assessed as inhibition of [3H]GABA uptake measured after 40 mins by LC-ESI-MS/MS analysi... | Citation and Details Article DOI: 10.1016/j.ejmech.2021.113512 BindingDB Entry DOI: 10.7270/Q2R21568 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent betaine transporter (Homo sapiens (Human)) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 7.17E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of human BGT1 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem 21: 4938-50 (2013) Article DOI: 10.1016/j.bmc.2013.06.063 BindingDB Entry DOI: 10.7270/Q2NZ891C | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium- and chloride-dependent GABA transporter 3 (Homo sapiens (Human)) | BDBM50039246 ((S)-1-(2-(tris(4-methoxyphenyl)methoxy)ethyl)piper...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokkaido University Curated by ChEMBL | Assay Description Inhibition of human GAT3 transfected in CHO cells assessed as [3H]GABA uptake after 20 mins by liquid scintillation counting analysis | Bioorg Med Chem 21: 4938-50 (2013) Article DOI: 10.1016/j.bmc.2013.06.063 BindingDB Entry DOI: 10.7270/Q2NZ891C | |||||||||||
More data for this Ligand-Target Pair |
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