BindingDB logo
myBDB logout

null

SMILES: COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)CO)cc1F

InChI Key: InChIKey=JCDSCTRINIXUJR-VIFPVBQESA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50039950   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Serine/threonine-protein kinase mTOR


(Homo sapiens (Human))		BDBM50039950
PNG
(CHEMBL3357870)
Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@@H](C)CO)cc1F |r|
Show InChI InChI=1S/C18H20FN7O2/c1-9(8-27)11-4-13(16-23-10(2)24-18(20)26-16)15(21-6-11)25-12-5-14(19)17(28-3)22-7-12/h4-7,9,27H,8H2,1-3H3,(H,21,25)(H2,20,23,24,26)/t9-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents

Similars
Article
PubMed
n/an/a>1.50E+4n/an/an/an/an/an/a



Amgen Inc.

Curated by ChEMBL


Assay Description
Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi...

Bioorg Med Chem Lett 24: 5630-4 (2014)


Article DOI: 10.1016/j.bmcl.2014.10.085
BindingDB Entry DOI: 10.7270/Q2GQ70CS
More data for this
Ligand-Target Pair