BDBM50039952 CHEMBL3357866

SMILES: COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)O)cc1F

InChI Key: InChIKey=RFMMTRCKHHKIJM-QMMMGPOBSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50039952   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM50039952 (CHEMBL3357866) Show SMILES COc1ncc(Nc2ncc(cc2-c2nc(C)nc(N)n2)[C@H](C)O)cc1F |r| Show InChI InChI=1S/C17H18FN7O2/c1-8(26)10-4-12(15-22-9(2)23-17(19)25-15)14(20-6-10)24-11-5-13(18)16(27-3)21-7-11/h4-8,26H,1-3H3,(H,20,24)(H2,19,22,23,25)/t8-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant N-terminally GST-tagged mTOR (1360 to 2549 aa) (unknown origin) assessed as inhibition of 27BP1 phosphorylation after 90 mi...				Bioorg Med Chem Lett 24: 5630-4 (2014) Article DOI: 10.1016/j.bmcl.2014.10.085 BindingDB Entry DOI: 10.7270/Q2GQ70CS
					More data for this Ligand-Target Pair