BDBM50042057 CHEMBL3360679

SMILES: Nc1c(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)cc2F)ccnc1NC(=O)CCl

InChI Key: InChIKey=XHACFLHDOUERTJ-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50042057   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50042057 (CHEMBL3360679) Show SMILES Nc1c(Oc2ccc(NC(=O)C3(CC3)C(=O)Nc3ccc(F)cc3)cc2F)ccnc1NC(=O)CCl Show InChI InChI=1S/C24H20ClF2N5O4/c25-12-19(33)32-21-20(28)18(7-10-29-21)36-17-6-5-15(11-16(17)27)31-23(35)24(8-9-24)22(34)30-14-3-1-13(26)2-4-14/h1-7,10-11H,8-9,12,28H2,(H,30,34)(H,31,35)(H,29,32,33)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	n/a	n/a
Soochow University Curated by ChEMBL					Assay Description Inhibition of recombinant c-Met (unknown origin) using poly (Glu,Tyr)4:1 substrate incubated for 60 mins by ELISA method				Bioorg Med Chem Lett 25: 708-16 (2015) Article DOI: 10.1016/j.bmcl.2014.11.070 BindingDB Entry DOI: 10.7270/Q21C1ZHD
					More data for this Ligand-Target Pair