BDBM50042963 (E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone::3,4-dihydroxychalcone::3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone::3-(3,4-dihydroxyphenyl)-1-phenylprop-2-en-1-one::CHEMBL129510
SMILES: Oc1ccc(\C=C\C(=O)c2ccccc2)cc1O
InChI Key: InChIKey=HHKVOYUYPYZFHJ-SOFGYWHQSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50042963![]() ((E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
Tokushima Bunri University Curated by ChEMBL | Assay Description In vitro inhibition against 5-lipoxygenase in RBL-1 cells was determined | J Med Chem 36: 3904-9 (1994) BindingDB Entry DOI: 10.7270/Q2MS3RT4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Xanthine dehydrogenase (Bos taurus (Bovine)) | BDBM50042963![]() ((E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 5.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Northern Kentucky University Curated by ChEMBL | Assay Description Inhibition of bovine xanthine oxidase assessed as conversion of xanthine to uric acid by spectroscopic analysis | Bioorg Med Chem 24: 578-87 (2016) BindingDB Entry DOI: 10.7270/Q23F4RJT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1) | BDBM50042963![]() ((E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone | ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | n/a | n/a | 2.29E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Tennessee Health Science Center Curated by ChEMBL | Assay Description Inhibitory activity against HIV-1 Integrase (HIV-1-IN) | J Med Chem 45: 841-52 (2002) BindingDB Entry DOI: 10.7270/Q28W3FGV | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Arachidonate 5-lipoxygenase (Rattus norvegicus) | BDBM50042963![]() ((E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone | ...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article | n/a | n/a | 43 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of 5-lipoxygenase in rat RBL1 cells | Citation and Details Article DOI: 10.1007/s00044-013-0745-7 BindingDB Entry DOI: 10.7270/Q22N53QB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1) | BDBM50042963![]() ((E)-3-(3,4-Dihydroxy-phenyl)-1-phenyl-propenone | ...) | PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Roma"La Sapienza" Curated by ChEMBL | Assay Description Compound concentration required to reduce HIV-1 Integrase 3'-processing activity by 50% | J Med Chem 41: 3948-60 (1998) Article DOI: 10.1021/jm9707232 BindingDB Entry DOI: 10.7270/Q29024G3 | |||||||||||
More data for this Ligand-Target Pair |