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BDBM50051183 (3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester::CHEMBL16108

SMILES: FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1

InChI Key: InChIKey=GVQMFQFMGQOLDL-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50051183   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
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Article
PubMed
19n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.


J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
Reactome pathway
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UniProtKB/SwissProt

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CHEMBL
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PC sid
UniChem

Patents


Similars

Article
PubMed
19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated


J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H2 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
UniProtKB/SwissProt

GoogleScholar
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CHEMBL
PC cid
PC sid
UniChem

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Article
PubMed
1.26E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H2 receptor of Guinea pig atrium


J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair
Histamine H1 receptor


(Cavia porcellus (domestic guinea pig))
BDBM50051183
PNG
((3-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...)
Show SMILES FC(F)(F)c1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)10-3-1-4-11(7-10)20-13(21)22-6-2-5-12-8-18-9-19-12/h1,3-4,7-9H,2,5-6H2,(H,18,19)(H,20,21)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
6.31E+4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity against H1 receptor of Guinea pig ileum


J Med Chem 39: 1157-63 (1996)


Article DOI: 10.1021/jm9507688
BindingDB Entry DOI: 10.7270/Q2SF2V7G
More data for this
Ligand-Target Pair