BDBM50051205 (2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)-propyl ester::CHEMBL16373

SMILES: FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1

InChI Key: InChIKey=VEWFQFWYYLBEGH-UHFFFAOYSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50051205   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50051205 ((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...) Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1 Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	24	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description In vitro antagonistic activity of the compound against Histamine H3 receptor on Synaptosomes of rat cerebral cortex.				J Med Chem 39: 1157-63 (1996) Article DOI: 10.1021/jm9507688 BindingDB Entry DOI: 10.7270/Q2SF2V7G
					More data for this Ligand-Target Pair
Histamine H3 receptor (Rattus norvegicus (rat))	BDBM50051205 ((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...) Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1 Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	25.1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Binding affinity against Histamine H3 receptor on Synaptosomes from rat cerebral cortex was evaluated				J Med Chem 39: 1157-63 (1996) Article DOI: 10.1021/jm9507688 BindingDB Entry DOI: 10.7270/Q2SF2V7G
					More data for this Ligand-Target Pair
Histamine H1 receptor (Cavia porcellus (domestic guinea pig))	BDBM50051205 ((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...) Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1 Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	3.98E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Binding affinity against H1 receptor of Guinea pig ileum				J Med Chem 39: 1157-63 (1996) Article DOI: 10.1021/jm9507688 BindingDB Entry DOI: 10.7270/Q2SF2V7G
					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM50051205 ((2-Trifluoromethyl-phenyl)-carbamic acid 3-(1H-imi...) Show SMILES FC(F)(F)c1ccccc1NC(=O)OCCCc1cnc[nH]1 Show InChI InChI=1S/C14H14F3N3O2/c15-14(16,17)11-5-1-2-6-12(11)20-13(21)22-7-3-4-10-8-18-9-19-10/h1-2,5-6,8-9H,3-4,7H2,(H,18,19)(H,20,21)	UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Freie Universität Berlin Curated by ChEMBL					Assay Description Binding affinity against H2 receptor of Guinea pig atrium				J Med Chem 39: 1157-63 (1996) Article DOI: 10.1021/jm9507688 BindingDB Entry DOI: 10.7270/Q2SF2V7G
					More data for this Ligand-Target Pair