BDBM50051827 CHEMBL283697::[4-((R)-2-Amino-3-mercapto-propyl)-piperazin-1-yl]-(2,3-dimethyl-phenyl)-methanone

SMILES: Cc1cccc(C(=O)N2CCN(C[C@@H](N)CS)CC2)c1C

InChI Key: InChIKey=VWWKWHDMKOYXDR-CQSZACIVSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50051827   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM50051827 (CHEMBL283697 | [4-((R)-2-Amino-3-mercapto-propyl)-...) Show SMILES Cc1cccc(C(=O)N2CCN(C[C@@H](N)CS)CC2)c1C Show InChI InChI=1S/C16H25N3OS/c1-12-4-3-5-15(13(12)2)16(20)19-8-6-18(7-9-19)10-14(17)11-21/h3-5,14,21H,6-11,17H2,1-2H3/t14-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of bovine Geranylgeranyl transferase type I				J Med Chem 39: 1345-8 (1996) Article DOI: 10.1021/jm9508090 BindingDB Entry DOI: 10.7270/Q2B8576Z
					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM50051827 (CHEMBL283697 | [4-((R)-2-Amino-3-mercapto-propyl)-...) Show SMILES Cc1cccc(C(=O)N2CCN(C[C@@H](N)CS)CC2)c1C Show InChI InChI=1S/C16H25N3OS/c1-12-4-3-5-15(13(12)2)16(20)19-8-6-18(7-9-19)10-14(17)11-21/h3-5,14,21H,6-11,17H2,1-2H3/t14-/m1/s1	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into Ha-Ras by Farnesyltransferase				J Med Chem 39: 1345-8 (1996) Article DOI: 10.1021/jm9508090 BindingDB Entry DOI: 10.7270/Q2B8576Z
					More data for this Ligand-Target Pair