BDBM50052609 3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-naphthalen-2-yl-propionamide::CHEMBL323009

SMILES: NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc2ccccc2c1

InChI Key: InChIKey=DRHOOZJDKQHCEL-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50052609   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM50052609 (3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-3-naphthal...) Show SMILES NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc2ccccc2c1 Show InChI InChI=1S/C21H16N2O3/c22-19(24)12-18(15-10-9-13-5-1-2-6-14(13)11-15)23-20(25)16-7-3-4-8-17(16)21(23)26/h1-11,18H,12H2,(H2,22,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of TNF-alpha production in LPS stimulated human PBMCs				J Med Chem 39: 3238-40 (1996) Article DOI: 10.1021/jm9603328 BindingDB Entry DOI: 10.7270/Q2V40T9Q
					More data for this Ligand-Target Pair