BDBM50052616 3-(3,4-Dichloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionamide::CHEMBL320347

SMILES: NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(Cl)c(Cl)c1

InChI Key: InChIKey=KKDBECFBNZZIPX-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50052616   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tumor necrosis factor (Homo sapiens (Human))	BDBM50052616 (3-(3,4-Dichloro-phenyl)-3-(1,3-dioxo-1,3-dihydro-i...) Show SMILES NC(=O)CC(N1C(=O)c2ccccc2C1=O)c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C17H12Cl2N2O3/c18-12-6-5-9(7-13(12)19)14(8-15(20)22)21-16(23)10-3-1-2-4-11(10)17(21)24/h1-7,14H,8H2,(H2,20,22)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	7.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Celgene Corporation Curated by ChEMBL					Assay Description Inhibition of TNF-alpha production in LPS stimulated human PBMCs				J Med Chem 39: 3238-40 (1996) Article DOI: 10.1021/jm9603328 BindingDB Entry DOI: 10.7270/Q2V40T9Q
					More data for this Ligand-Target Pair