BDBM50053648 (R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid methyl ester::CHEMBL340523
SMILES: CCc1ccc(cc1)C1CC2CCC(N2)C1C(=O)OC
InChI Key: InChIKey=VQVUZWDWIQWSQU-UHFFFAOYSA-N
Data: 6 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of [3H]paroxetine binding to serotonin transporter in rat frontal cortex | J Med Chem 39: 4027-35 (1996) Article DOI: 10.1021/jm960409s BindingDB Entry DOI: 10.7270/Q22B8ZNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of [3H]nisoxetine binding to the norepinephrine transporter in rat midbrain. | J Med Chem 39: 4027-35 (1996) Article DOI: 10.1021/jm960409s BindingDB Entry DOI: 10.7270/Q22B8ZNT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description In vitro inhibitory activity against radioligand [3H]paroxetine binding to serotonin transporter (5-HTT) in rat midbrain tissue | J Med Chem 40: 3861-4 (1998) Article DOI: 10.1021/jm970492z BindingDB Entry DOI: 10.7270/Q2GX4C7G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Norepinephrine Monoamine transporters (Rattus norvegicus) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | Reactome pathway KEGG UniProtKB/TrEMBL GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 122 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description In vitro inhibitory activity against radioligand [3H]-nisoxatine binding to norepinephrine transporter (NET) in rat cortical tissue | J Med Chem 40: 3861-4 (1998) Article DOI: 10.1021/jm970492z BindingDB Entry DOI: 10.7270/Q2GX4C7G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description In vitro inhibitory activity against radioligand [3H]-WN 35,428 binding to dopamine transporter (DAT) in rat striatal tissue | J Med Chem 40: 3861-4 (1998) Article DOI: 10.1021/jm970492z BindingDB Entry DOI: 10.7270/Q2GX4C7G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM50053648 ((R)-3-(4-Ethyl-phenyl)-8-aza-bicyclo[3.2.1]octane-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
Research Triangle Institute Curated by ChEMBL | Assay Description Inhibition of [3H]WIN-35428 binding to the dopamine transporter in rat striata. | J Med Chem 39: 4027-35 (1996) Article DOI: 10.1021/jm960409s BindingDB Entry DOI: 10.7270/Q22B8ZNT | |||||||||||
More data for this Ligand-Target Pair |