BDBM50054591 (Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopropyl-3-hydroxy-acrylamide::CHEMBL141104

SMILES: Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1Cl

InChI Key: InChIKey=MBVWUNQMPJDNBR-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50054591   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (Mus musculus)	BDBM50054591 ((Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopr...) Show SMILES Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1Cl Show InChI InChI=1S/C14H13ClN2O2/c1-8-2-5-10(6-12(8)15)17-14(19)11(7-16)13(18)9-3-4-9/h2,5-6,9,11H,3-4H2,1H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	282	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibitory concentration tested on enzyme dihydroorotate dehydrogenase in mouse				J Med Chem 39: 4608-21 (1996) Article DOI: 10.1021/jm9604437 BindingDB Entry DOI: 10.7270/Q20G3KSX
					More data for this Ligand-Target Pair
Dihydroorotate Dehydrogenase (DHODH) (Rattus norvegicus (rat))	BDBM50054591 ((Z)-N-(3-Chloro-4-methyl-phenyl)-2-cyano-3-cyclopr...) Show SMILES Cc1ccc(NC(=O)C(C#N)C(=O)C2CC2)cc1Cl Show InChI InChI=1S/C14H13ClN2O2/c1-8-2-5-10(6-12(8)15)17-14(19)11(7-16)13(18)9-3-4-9/h2,5-6,9,11H,3-4H2,1H3,(H,17,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	79	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Marion Roussel Curated by ChEMBL					Assay Description Inhibitory concentration tested against enzyme dihydroorotate dehydrogenase in rat				J Med Chem 39: 4608-21 (1996) Article DOI: 10.1021/jm9604437 BindingDB Entry DOI: 10.7270/Q20G3KSX
					More data for this Ligand-Target Pair