BindingDB PrimarySearch

BDBM50055675 4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benzoic acid 2-(4-hydroxy-benzoylamino)-8-methyl-8-aza-bicyclo[3.2.1]oct-3-yl ester::CHEMBL306883

SMILES: CN1C2CCC1C(NC(=O)c1ccc(O)cc1)C(C2)OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2C(O)=O)c(O)c1

InChI Key: InChIKey=DWBQHQGWEQXPKL-UHFFFAOYSA-N

Data: 17 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50055675
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C beta 1 isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C beta 1				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C alpha type (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C alpha isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, gamma (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C gamma isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C, epsilon (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C epsilon isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C beta 2 isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C delta type (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C delta isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
Protein kinase C (PKC) (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C zeta isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration of the compound against recombinant human cAMP-dependent Protein kinase A				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	3.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C beta 1				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C iota type/zeta type (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C delta				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
cAMP-dependent protein kinase (PKA) (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C beta 1				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
PKC alpha and beta-2 (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description PKC was assayed by quantitating the incorporation of 32P from [gamma-32P]ATP into histone type IIIs.				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C beta 2				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C, PKC; classical/novel (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Sphinx Laboratories					Assay Description Inhibition of Protein kinase C zeta				Bioorg Med Chem Lett 5: 2211-6 (1995) Article DOI: 10.1016/0960-894X(95)00382-4 BindingDB Entry DOI: 10.7270/Q2QR4V9M
Sphinx Laboratories					More data for this Ligand-Target Pair
Protein kinase C, eta (Homo sapiens (Human))	BDBM50055675 (4-(2-Carboxy-6-hydroxy-benzoyl)-3,5-dihydroxy-benz...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
A Division of Eli Lilly & Company Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human Protein kinase C eta isozyme				J Med Chem 40: 226-35 (1997) Article DOI: 10.1021/jm960497g BindingDB Entry DOI: 10.7270/Q2J965HR
A Division of Eli Lilly & Company Curated by ChEMBL					More data for this Ligand-Target Pair