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SMILES: Cn1cc([C@H]2CC[C@H](CCN3CCN(CC3)c3ccccn3)CC2)c2ccccc12

InChI Key: InChIKey=LACILEXWDGRNHN-HZCBDIJESA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50055728   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50055728
PNG
(1-Methyl-3-{4-[2-(4-pyridin-2-yl-piperazin-1-yl)-e...)
Show SMILES Cn1cc([C@H]2CC[C@H](CCN3CCN(CC3)c3ccccn3)CC2)c2ccccc12 |wU:4.3,wD:7.7,(6,-13.07,;6.54,-11.62,;8.02,-11.23,;8.1,-9.67,;9.38,-8.82,;9.37,-7.29,;10.72,-6.52,;12.03,-7.29,;13.38,-6.54,;14.69,-7.29,;16.04,-6.56,;17.37,-7.29,;18.7,-6.54,;18.68,-4.98,;17.34,-4.23,;16.01,-5.02,;20.02,-4.21,;21.35,-4.98,;22.68,-4.21,;22.66,-2.67,;21.34,-1.9,;19.99,-2.67,;12.03,-8.83,;10.72,-9.59,;6.64,-9.14,;6.1,-7.71,;4.59,-7.45,;3.59,-8.67,;4.15,-10.12,;5.68,-10.34,)|
Show InChI InChI=1S/C26H34N4/c1-28-20-24(23-6-2-3-7-25(23)28)22-11-9-21(10-12-22)13-15-29-16-18-30(19-17-29)26-8-4-5-14-27-26/h2-8,14,20-22H,9-13,15-19H2,1H3/t21-,22-
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Article
PubMed
 83n/an/an/an/an/an/an/an/a



Division of Warner Lambert Company

Curated by ChEMBL


Assay Description
In vitro binding affinity for dopamine receptor D2 on rat striatal membranes by [3H]-spiperone displacement.

J Med Chem 40: 250-9 (1997)


Article DOI: 10.1021/jm960597m
BindingDB Entry DOI: 10.7270/Q28W3CD4
More data for this
Ligand-Target Pair