BDBM50056678 CHEMBL3341792

SMILES: Nc1ncc(cc1-c1ccnc2ccccc12)-c1cccc(c1)N1CCNCC1

InChI Key: InChIKey=OWGBNDVAAXWRCD-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50056678   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Activin receptor type-1 (Homo sapiens (Human))	BDBM50056678 (CHEMBL3341792) Show SMILES Nc1ncc(cc1-c1ccnc2ccccc12)-c1cccc(c1)N1CCNCC1 Show InChI InChI=1S/C24H23N5/c25-24-22(20-8-9-27-23-7-2-1-6-21(20)23)15-18(16-28-24)17-4-3-5-19(14-17)29-12-10-26-11-13-29/h1-9,14-16,26H,10-13H2,(H2,25,28)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts Institute of Technology Curated by ChEMBL					Assay Description Inhibition of human recombinant human ALK2 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]				J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50056678 (CHEMBL3341792) Show SMILES Nc1ncc(cc1-c1ccnc2ccccc12)-c1cccc(c1)N1CCNCC1 Show InChI InChI=1S/C24H23N5/c25-24-22(20-8-9-27-23-7-2-1-6-21(20)23)15-18(16-28-24)17-4-3-5-19(14-17)29-12-10-26-11-13-29/h1-9,14-16,26H,10-13H2,(H2,25,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts Institute of Technology Curated by ChEMBL					Assay Description Inhibition of TGFbeta1-induced TGFbeta type 1 ALK5 in HEK293T cells after 30 mins by luciferase reporter gene assay				J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6
					More data for this Ligand-Target Pair
ALK2 (Mus musculus)	BDBM50056678 (CHEMBL3341792) Show SMILES Nc1ncc(cc1-c1ccnc2ccccc12)-c1cccc(c1)N1CCNCC1 Show InChI InChI=1S/C24H23N5/c25-24-22(20-8-9-27-23-7-2-1-6-21(20)23)15-18(16-28-24)17-4-3-5-19(14-17)29-12-10-26-11-13-29/h1-9,14-16,26H,10-13H2,(H2,25,28)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	520	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts Institute of Technology Curated by ChEMBL					Assay Description Inhibition of BMP6-induced BMP receptor type 1 ALK2 in mouse C2C12 cells after 30 mins by luciferase reporter gene assay				J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6
					More data for this Ligand-Target Pair
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50056678 (CHEMBL3341792) Show SMILES Nc1ncc(cc1-c1ccnc2ccccc12)-c1cccc(c1)N1CCNCC1 Show InChI InChI=1S/C24H23N5/c25-24-22(20-8-9-27-23-7-2-1-6-21(20)23)15-18(16-28-24)17-4-3-5-19(14-17)29-12-10-26-11-13-29/h1-9,14-16,26H,10-13H2,(H2,25,28)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Massachusetts Institute of Technology Curated by ChEMBL					Assay Description Inhibition of purified human ALK5 kinase after 45 mins by liquid scintillation counting in presence of ATP [gamma-32P]				J Med Chem 57: 7900-15 (2014) Article DOI: 10.1021/jm501177w BindingDB Entry DOI: 10.7270/Q2PK0HS6
					More data for this Ligand-Target Pair