BDBM50056945 4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-yl)-piperazin-1-yl]-ethyl}-benzamide::CHEMBL177031

SMILES: Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12

InChI Key: InChIKey=FGNDDXTVXSKQJK-UHFFFAOYSA-N

Data: 11 KI  2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50056945   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Displacement of [3H]8-OH-DPAT from 5-hydroxytryptamine 1A receptor of rat hippocampal membranes				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatum				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]DTG binding to sigma receptor in rat hippocampus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]DTG binding to sigma receptor in rat hippocampus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid Plexus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
D(2) dopamine receptor (BOVINE)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	700	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]raclopride binding to Dopamine receptor D2 of bovine striatum				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortex				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
D(3) dopamine receptor (Homo sapiens (Human))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]spiperone binding to Dopamine receptor D3 in bovine cortex				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2C (Homo sapiens (Human))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.23E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]mesulergine binding to 5-hydroxytryptamine 1C receptor of pig choroid Plexus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
DRD1 (BOVINE)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
DRD1 (BOVINE)	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.70E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of [3H]SCH-23390 binding to Dopamine receptor D1 of bovine striatum				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	75	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 1A (Rattus norvegicus (rat))	BDBM50056945 (4-Chloro-N-{2-[4-(1,2,3,4-tetrahydro-naphthalen-1-...) Show SMILES Clc1ccc(cc1)C(=O)NCCN1CCN(CC1)C1CCCc2ccccc12 Show InChI InChI=1S/C23H28ClN3O/c24-20-10-8-19(9-11-20)23(28)25-12-13-26-14-16-27(17-15-26)22-7-3-5-18-4-1-2-6-21(18)22/h1-2,4,6,8-11,22H,3,5,7,12-17H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cooperation Pharmaceutique Fran�aise Curated by ChEMBL					Assay Description Inhibition of forskolin-activated adenylate cyclase (cAMP) activity at 5-hydroxytryptamine 1A receptor in rat hippocampus				J Med Chem 40: 952-60 (1997) Article DOI: 10.1021/jm950759z BindingDB Entry DOI: 10.7270/Q2HT2Q00
					More data for this Ligand-Target Pair