BDBM50057297 (5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7,7a,8,9,10,10a,10b,11,12-dodecahydro-5aH-indeno[4,5-c]quinolizin-2-one::CHEMBL269632

SMILES: C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O

InChI Key: InChIKey=UTDXFFWXJOMGPG-WOYTXXSLSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50057297   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Steroid 5-alpha-reductase (Homo sapiens (Human))	BDBM50057297 ((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...) Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O |t:8| Show InChI InChI=1S/C17H25NO2/c1-17-8-6-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)7-9-18(11)15/h10,13-16,20H,2-9H2,1H3/t13-,14-,15-,16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.70	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Firenze Curated by ChEMBL					Assay Description Inhibition against 5 alpha R-2 in human prostate homogenate relative to finasteride				J Med Chem 40: 1112-29 (1997) Article DOI: 10.1021/jm960807v BindingDB Entry DOI: 10.7270/Q2D21Z8K
					More data for this Ligand-Target Pair
Steroid 5-alpha-reductase (Homo sapiens (Human))	BDBM50057297 ((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...) Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O |t:8| Show InChI InChI=1S/C17H25NO2/c1-17-8-6-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)7-9-18(11)15/h10,13-16,20H,2-9H2,1H3/t13-,14-,15-,16-,17-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against 5-alpha Reductase-2 on human prostate homogenates from surgically derived benign hyperplastic tissue				J Med Chem 40: 1112-29 (1997) Article DOI: 10.1021/jm960807v BindingDB Entry DOI: 10.7270/Q2D21Z8K
					More data for this Ligand-Target Pair
5α-Reductase 1 (5α-R1) (Homo sapiens (Human))	BDBM50057297 ((5aS,7aS,8S,10aS,10bS)-8-Hydroxy-7a-methyl-3,4,6,7...) Show SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CCN34)[C@@H]1CC[C@@H]2O |t:8| Show InChI InChI=1S/C17H25NO2/c1-17-8-6-15-13(14(17)4-5-16(17)20)3-2-11-10-12(19)7-9-18(11)15/h10,13-16,20H,2-9H2,1H3/t13-,14-,15-,16-,17-/m0/s1	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	409	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ di Firenze Curated by ChEMBL					Assay Description Inhibitory activity against human 5-alpha Reductase-1 expressed in DU-145 cells				J Med Chem 40: 1112-29 (1997) Article DOI: 10.1021/jm960807v BindingDB Entry DOI: 10.7270/Q2D21Z8K
					More data for this Ligand-Target Pair