BDBM50057984 2-(3-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4-trifluoromethyl-1H-imidazole::CHEMBL42175

SMILES: CS(=O)(=O)c1ccc(cc1)-n1cc(nc1-c1cccc(Cl)c1)C(F)(F)F

InChI Key: InChIKey=YLFBPUKBMRJHLM-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50057984   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclooxygenase-1 (COX-1) (Homo sapiens (Human))	BDBM50057984 (2-(3-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...) Show SMILES CS(=O)(=O)c1ccc(cc1)-n1cc(nc1-c1cccc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C17H12ClF3N2O2S/c1-26(24,25)14-7-5-13(6-8-14)23-10-15(17(19,20)21)22-16(23)11-3-2-4-12(18)9-11/h2-10H,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.60E+5	n/a	n/a	n/a	n/a	n/a	n/a
Searle Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit human prostaglandin G/H synthase 1 (COX-1) by 50%				J Med Chem 40: 1634-47 (1997) Article DOI: 10.1021/jm9700225 BindingDB Entry DOI: 10.7270/Q2F76BN0
					More data for this Ligand-Target Pair
Cyclooxygenase-2 (COX-2) (Mus musculus (Mouse))	BDBM50057984 (2-(3-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...) Show SMILES CS(=O)(=O)c1ccc(cc1)-n1cc(nc1-c1cccc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C17H12ClF3N2O2S/c1-26(24,25)14-7-5-13(6-8-14)23-10-15(17(19,20)21)22-16(23)11-3-2-4-12(18)9-11/h2-10H,1H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	n/a
University of Hyderabad Curated by ChEMBL					Assay Description Inhibitory activity against prostaglandin G/H synthase 2 (COX-2)				J Med Chem 45: 4847-57 (2002) BindingDB Entry DOI: 10.7270/Q2SX6FFJ
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50057984 (2-(3-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...) Show SMILES CS(=O)(=O)c1ccc(cc1)-n1cc(nc1-c1cccc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C17H12ClF3N2O2S/c1-26(24,25)14-7-5-13(6-8-14)23-10-15(17(19,20)21)22-16(23)11-3-2-4-12(18)9-11/h2-10H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	60.3	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ de Lille 2 Curated by ChEMBL					Assay Description Inhibition of human Prostaglandin G/H synthase 2				J Med Chem 44: 3223-30 (2001) BindingDB Entry DOI: 10.7270/Q2736S4D
					More data for this Ligand-Target Pair
Cyclooxygenase (Homo sapiens (Human))	BDBM50057984 (2-(3-Chloro-phenyl)-1-(4-methanesulfonyl-phenyl)-4...) Show SMILES CS(=O)(=O)c1ccc(cc1)-n1cc(nc1-c1cccc(Cl)c1)C(F)(F)F Show InChI InChI=1S/C17H12ClF3N2O2S/c1-26(24,25)14-7-5-13(6-8-14)23-10-15(17(19,20)21)22-16(23)11-3-2-4-12(18)9-11/h2-10H,1H3	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	60	n/a	n/a	n/a	n/a	n/a	n/a
Searle Research and Development Curated by ChEMBL					Assay Description Concentration required to inhibit human Prostaglandin G/H synthase 2 (COX-2) by 50%				J Med Chem 40: 1634-47 (1997) Article DOI: 10.1021/jm9700225 BindingDB Entry DOI: 10.7270/Q2F76BN0
					More data for this Ligand-Target Pair