BDBM50059106 6-Chloro-2-(4-fluoro-phenyl)-1H-[1,8]naphthyridin-4-one::CHEMBL51729

SMILES: Oc1cc(nc2ncc(Cl)cc12)-c1ccc(F)cc1

InChI Key: InChIKey=UHXBIVBUQZJQAF-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50059106   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tubulin (Sus scrofa (Pig))	BDBM50059106 (6-Chloro-2-(4-fluoro-phenyl)-1H-[1,8]naphthyridin-...) Show SMILES Oc1cc(nc2ncc(Cl)cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C14H8ClFN2O/c15-9-5-11-13(19)6-12(18-14(11)17-7-9)8-1-3-10(16)4-2-8/h1-7H,(H,17,18,19)	PDB MMDB UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1.58E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill Curated by ChEMBL					Assay Description Inhibition of tubulin polymerization interacting at the colchicine binding site.				J Med Chem 43: 167-76 (2000) BindingDB Entry DOI: 10.7270/Q2CV4JZB
					More data for this Ligand-Target Pair
Tubulin (Bos taurus)	BDBM50059106 (6-Chloro-2-(4-fluoro-phenyl)-1H-[1,8]naphthyridin-...) Show SMILES Oc1cc(nc2ncc(Cl)cc12)-c1ccc(F)cc1 Show InChI InChI=1S/C14H8ClFN2O/c15-9-5-11-13(19)6-12(18-14(11)17-7-9)8-1-3-10(16)4-2-8/h1-7H,(H,17,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina at Chapel Hill 27599 Curated by ChEMBL					Assay Description Inhibition of bovine tubulin polymerization				J Med Chem 40: 2266-75 (1997) Article DOI: 10.1021/jm960858s BindingDB Entry DOI: 10.7270/Q26M35ZF
					More data for this Ligand-Target Pair