BDBM50061221 2-(3,5-Dichloro-phenyl)-N-[(R)-2-oxo-5-phenyl-1-(2,2,2-trifluoro-ethyl)-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]-acetamide::CHEMBL339327

SMILES: FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)Cc2cc(Cl)cc(Cl)c2)C1=O)c1ccccc1

InChI Key: InChIKey=CUYBFAFDHAPZGW-HSZRJFAPSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50061221   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50061221 (2-(3,5-Dichloro-phenyl)-N-[(R)-2-oxo-5-phenyl-1-(2...) Show SMILES FC(F)(F)CN1c2ccccc2C(=N[C@@H](NC(=O)Cc2cc(Cl)cc(Cl)c2)C1=O)c1ccccc1 |c:13| Show InChI InChI=1S/C25H18Cl2F3N3O2/c26-17-10-15(11-18(27)13-17)12-21(34)31-23-24(35)33(14-25(28,29)30)20-9-5-4-8-19(20)22(32-23)16-6-2-1-3-7-16/h1-11,13,23H,12,14H2,(H,31,34)/t23-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibition of Ikr current in isolated guinea pig myocytes during a 0.5 s voltage clamp step from -50 to -10 mV.				J Med Chem 40: 3865-8 (1998) Article DOI: 10.1021/jm970517u BindingDB Entry DOI: 10.7270/Q2Q81C6H
					More data for this Ligand-Target Pair