BDBM50065794 8-Hydroxy-2-methyl-quinoline-7-carboxylic acid::8-hydroxy-2-methylquinoline-7-carboxylic acid::CHEMBL39823

SMILES: Cc1ccc2ccc(C(O)=O)c(O)c2n1

InChI Key: InChIKey=SHOHIXCIFBPUAP-UHFFFAOYSA-N

Data: 7 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50065794   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description HIV integrase inhibitory potency of the compound was evaluated as IC50 on 3' processing of target DNA.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.14E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description In vitro anti-HIV integrase activity of the compound was tested against integration(strand transfer) of target plasmid.				J Med Chem 41: 2846-57 (1998) Article DOI: 10.1021/jm980043e BindingDB Entry DOI: 10.7270/Q21Z43JH
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 Integrase in 3'-end- processing				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Silesia Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase				Bioorg Med Chem 19: 5000-5 (2011) Article DOI: 10.1016/j.bmc.2011.06.054 BindingDB Entry DOI: 10.7270/Q2SN0CTM
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Universit£ Paris Sud Curated by ChEMBL					Assay Description Inhibition of PIM1				Bioorg Med Chem Lett 20: 2801-5 (2010) Article DOI: 10.1016/j.bmcl.2010.03.061 BindingDB Entry DOI: 10.7270/Q2125STS
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Jadavpur University Curated by ChEMBL					Assay Description Inhibition of HIV1 integrase 3' processing activity				Eur J Med Chem 43: 81-92 (2008) Article DOI: 10.1016/j.ejmech.2007.02.021 BindingDB Entry DOI: 10.7270/Q24170XZ
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 integrase (Human immunodeficiency virus 1)	BDBM50065794 (8-Hydroxy-2-methyl-quinoline-7-carboxylic acid | 8...) Show SMILES Cc1ccc2ccc(C(O)=O)c(O)c2n1 Show InChI InChI=1S/C11H9NO3/c1-6-2-3-7-4-5-8(11(14)15)10(13)9(7)12-6/h2-5,13H,1H3,(H,14,15)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Université Paris-Sud Curated by ChEMBL					Assay Description Inhibitory activity against HIV-1 Integrase in strand transfer(integration)				J Med Chem 43: 1533-40 (2000) BindingDB Entry DOI: 10.7270/Q2JS9PNQ
					More data for this Ligand-Target Pair