BDBM50066068 CHEMBL28853::N-Acenaphthen-5-yl-N'-(4-methoxy-naphthalen-1-yl)-guanidine::N-Acenaphthen-5-yl-N'-(4-methoxy-naphthalen-1-yl)-guanidine(CNS1237)

SMILES: COc1ccc(N=C(N)Nc2ccc3CCc4cccc2c34)c2ccccc12

InChI Key: InChIKey=AZZRFSWIWLKNLQ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50066068   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 2 alpha subunit (Homo sapiens (Human))	BDBM50066068 (CHEMBL28853 | N-Acenaphthen-5-yl-N'-(4-methoxy-nap...) Show SMILES COc1ccc(N=C(N)Nc2ccc3CCc4cccc2c34)c2ccccc12 |w:6.5| Show InChI InChI=1S/C24H21N3O/c1-28-22-14-13-20(17-6-2-3-7-18(17)22)26-24(25)27-21-12-11-16-10-9-15-5-4-8-19(21)23(15)16/h2-8,11-14H,9-10H2,1H3,(H3,25,26,27)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article	n/a	n/a	1.31E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Blockade of synaptosomal sodium channels, inhibition of [14C]-guanidinium ion flux into CHO cells expressing Type II sodium channel				Bioorg Med Chem Lett 5: 2259-2262 (1995) Article DOI: 10.1016/0960-894X(95)00392-7 BindingDB Entry DOI: 10.7270/Q200022B
					More data for this Ligand-Target Pair
Sodium channel protein type II alpha subunit (Rattus norvegicus)	BDBM50066068 (CHEMBL28853 | N-Acenaphthen-5-yl-N'-(4-methoxy-nap...) Show SMILES COc1ccc(N=C(N)Nc2ccc3CCc4cccc2c34)c2ccccc12 |w:6.5| Show InChI InChI=1S/C24H21N3O/c1-28-22-14-13-20(17-6-2-3-7-18(17)22)26-24(25)27-21-12-11-16-10-9-15-5-4-8-19(21)23(15)16/h2-8,11-14H,9-10H2,1H3,(H3,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cambridge NeuroScience, Inc. Curated by ChEMBL					Assay Description Sodium channel block, determined by % block of [14C]guanidinium flux in CHO line expressing rat type IIA sodium channels derived from rat brain				J Med Chem 41: 3298-302 (1998) Article DOI: 10.1021/jm980134b BindingDB Entry DOI: 10.7270/Q2Q52Q8W
					More data for this Ligand-Target Pair
Sodium channel protein type II alpha subunit (Rattus norvegicus)	BDBM50066068 (CHEMBL28853 | N-Acenaphthen-5-yl-N'-(4-methoxy-nap...) Show SMILES COc1ccc(N=C(N)Nc2ccc3CCc4cccc2c34)c2ccccc12 |w:6.5| Show InChI InChI=1S/C24H21N3O/c1-28-22-14-13-20(17-6-2-3-7-18(17)22)26-24(25)27-21-12-11-16-10-9-15-5-4-8-19(21)23(15)16/h2-8,11-14H,9-10H2,1H3,(H3,25,26,27)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	1.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
Cambridge NeuroScience Inc. Curated by ChEMBL					Assay Description In vitro inhibition of [14C]- guanidinium influx in Chinese hamster ovary (CHO) cells expressing rat brain sodium channel type IIA (CNaIIA-1)				J Med Chem 41: 3048-61 (1998) Article DOI: 10.1021/jm980124a BindingDB Entry DOI: 10.7270/Q2R49RF5
					More data for this Ligand-Target Pair