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SMILES: CC(C)(CC(O)=O)CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C

InChI Key: InChIKey=JUKFCBROSYMBDZ-PMAZRIFVSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50067818   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50067818
PNG
(3,3-Dimethyl-pentanedioic acid mono-[2-((9R,10S,11...)
Show SMILES CC(C)(CC(O)=O)CC(=O)OCC(=O)[C@@]1(O)CCC2C3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C |t:22|
Show InChI InChI=1S/C28H39FO8/c1-24(2,13-22(33)34)14-23(35)37-15-21(32)27(36)10-8-18-19-6-5-16-11-17(30)7-9-25(16,3)28(19,29)20(31)12-26(18,27)4/h11,18-20,31,36H,5-10,12-15H2,1-4H3,(H,33,34)/t18?,19?,20-,25-,26-,27-,28-/m0/s1
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MMDB

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Article
PubMed
n/an/a 4.80E+4n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
inhibitory activity against human Farnesyltransferase

J Med Chem 41: 4492-501 (1998)


Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ
More data for this
Ligand-Target Pair