null
SMILES: CC(C)C(=O)OCC(=O)C1CCC2C3CCC(=O)[C@](C)(CCC(O)=O)C3C(=O)C[C@]12C
InChI Key: InChIKey=UHWOAYITUVVFCV-UZFKVVNJSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human)) | BDBM50067823![]() (CHEMBL138048 | Isobutyric acid 2-[(3aS,6R)-6-(2-ca...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories Curated by ChEMBL | Assay Description Inhibitory activity against human Farnesyltransferase | J Med Chem 41: 4492-501 (1998) Article DOI: 10.1021/jm980356+ BindingDB Entry DOI: 10.7270/Q23779DQ | |||||||||||
More data for this Ligand-Target Pair |