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SMILES: C[C@]12CC(=O)C3C(CCC(=O)[C@]3(C)C(O)=O)C1CC[C@@]21OCOC11COCO1

InChI Key: InChIKey=JHIUUDFRMGSNKB-QJNQNGBQSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50067832   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50067832
PNG
(3a,6-dimethyl-5,7-dioxo-(3'R,3aS,6R)-dispiro[perhy...)
Show SMILES C[C@]12CC(=O)C3C(CCC(=O)[C@]3(C)C(O)=O)C1CC[C@@]21OCOC11COCO1
Show InChI InChI=1S/C20H26O8/c1-17-7-13(21)15-11(3-4-14(22)18(15,2)16(23)24)12(17)5-6-19(17)20(28-10-26-19)8-25-9-27-20/h11-12,15H,3-10H2,1-2H3,(H,23,24)/t11?,12?,15?,17-,18-,19+,20?/m0/s1
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Article
PubMed
n/an/a>1.00E+5n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibitory activity against human Farnesyltransferase

J Med Chem 41: 4492-501 (1998)


Article DOI: 10.1021/jm980356+
BindingDB Entry DOI: 10.7270/Q23779DQ
More data for this
Ligand-Target Pair